Research Funding
Research Partners
Research Interests
We design algorithms to understand gene regulation and DNA damage and repair, to characterize disruptions of these processes in disease, and to discover therapeutic targets.
Computer Science
- Algorithms
- Machine learning
- Data mining
- combinatorial algorithms
- n-way clustering
- time course analysis
- domain-driven data integration
Molecular biology
- Transcriptional regulation
- Epigenetic regulation
- DNA damage and repair
- Gene expression
- TF-DNA binding
- Epigenomics
- Gene disruption and editing readouts (CRISPR + sequencing)
- Gene essentiality
- Mutation patterns and signatures
Biomedicine (cancer)
Focus on disruption of relationships and pathways rather than single functional elements (i.e. genes).
- Major regulation of disrupted pathways.
- Mechanisms involved in drug resistance.
- Gene essentiality and synthetic lethality relationships.
- DNA damage and repair.